TAFFIC is an anti-retroviral medicine TAF & Emtricitabine are nucleotide reverse transcriptase inhibitor Bictegravir are integrase inhibitor that involved in elimination of increase of HIV Virus relate with AIDS.Taffic is a fixed dose combination drug, Which include three superior factors like Tenofovir Alafenamide, Emtricitabine & Bictegravir Taffic is a prescription medicine, used by the patients only under the ability of medical expert.
Taffic, a combination tablet contains Tenofovir Alafenamide; Emtricitabine & Bictegravir is mainly indicated for the medicine of HIV-1 disease in adult’s patients.
MECHANISM OF ACTION
TAF is a strange ester prodrug of anti-retroviral Tenofovir, and it is a nucleotide reverse transcriptase inhibitor. ). By conflicting the common nucleotide for insertion into proviral DNA and barrier of formation of 5 to 3 phosphodiester correlation which is needed for DNA elongation Tenofovir leads to chain termination and block proviral DNA record. After an oral control, TAF is revolutionize into Tenofovir (acyclic nucleoside phosphonate analog of adenosine 5 monophosphate) Tenofovir expend DNA necessary, there is a lack of 3 OH molecules (water molecules are guilty for phosphodiester bond similarity.
Emtricitabine is one of the factors of Taffic; it performance its anti-retroviral action by inhibiting reverse transcriptase, the incentive which is responsible for transcription HIV RNA into new viral DNA. Emtricitabine 5 phosphates is HIV-1 reverse transcriptase inhibitor Emtricitabine 5 phosphates fight with deoxycytidine 5 triphosphate (natural substrate) and added into viral DNA causes chain termination. Emtricitabine is phosphorylated to Emtricitabine 5 phosphate with the benefit of cellular enzymes.
HIV-1 integrase strand transfer inhibitor (INSTI). Bictegravir (BIC) inhibits string transfer of viral DNA into performs the genome and thereby forbid HIV-1 replication. It is a novel INSTI that can be dosed once daily without sustain.
Taffic; the assimilation of Tenofovir is occur fastly and its Tmax is detected at 1 hour after organization; whereas Emtricitabine is consumed rapidly and its mean bioavailability is 93%; whereas Bictegravir is involved in oral administration is followed by peak plasma absorption occurring at 2.0-4.0 hours after organization.
The human plasma protein is obligated of Emtricitabine is very low less than 4% Tenofovir is highly obligated to human plasma protein with the range of 80% Bictegravir and human plasma protein is obligated to very more greater than 99%
TAF is determined into Tenofovir within the cells, it is the major metabolite again phosphorylated into Tenofovir diphosphate effective metabolite. Emtricitabine is minimally and it is found in urine as unaffected form. Bictegravir is the minor pathway evacuation of undamaged & eliminated by hepatic metabolism.
The route of expulsion mostly through urine, the fatal half life of Emtricitabine is 10 hours the fatal half life period of Tenofovir is 0.51 hour the fatal half life period of Bictegravir is 17.3 hours.
DOSAGE AND ADMINISTRATION
The recommended dose of Taffic in the position of HIV-1 infection in adults is, one tablet should be taken once day-to-day with or without food. In Pre- liability Prophylaxis: uninfected adults should take one tablet orally as a single dose.
COMMON SIDE EFFECTS
- Abnormal dreams,
- Giddiness, and.
Taffic should be used carefully, during the therapy some of injurious effects occur; Immune reconstitution syndrome lactic acidosis Hepatomegaly with steatosis renal toxicity intense or serious exacerbations of HBV occurs during discontinuation of anti-retroviral therapy renal impairment. Protections to inhibit transmission should be taken in accordance with national guidelines.
PREGNANCY & LACTATION
The custom of Taffic during pregnancy stage is only appeared by knowing the risk advantage combine to Taffic.
The storehouse of Taffic should be conserved at a temperature below 30℃
Preserve the container from steam, heat & luminous.