Lenangio-5mg

Lenangio 5mg  has existed to anticancer medication which consists of Lenalidomide active stuff that exists to thalidomide analog.  Lenangio 5mg  is used to the disease is action by... read more

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LENANGIO 5MG

DESCRIPTION

Lenangio 5mg has existed to anticancer medication which consists of Lenalidomide active stuff that exists to thalidomide analog. Lenangio 5mg is used to the disease is action by combining with dexamethasone. Lenangio 5mg consist of some other pharmacological movement like immunomodulatory & anti-angiogenesis. Lenangio 5mg is a medicine drug that can only use under the administration of medical oncologists.

INDICATION

The indications of Lenangio 5mg are;

Lenangio combination with dexamethasone is determined to pleasure the patients undergo from multiple myeloma. It is determined for the inmate to carry transfer- reliant anemia because of in-between 1 risk myelodysplastic syndrome along with expunction 5q cytogenetic abnormality without or without addition cytogenetic abnormalities. Lenangio is used to delight the patients with mantle cell lymphoma in which it used who’s the disease was deterioration or continue after two before treatment, particularly the disease not reaction with the bortezomib therapy.

DOSAGE

The adult common dose of Lenangio 5mg in myelodysplastic problem is 10mg and execute once a day.

For renal broken patients

CrCl >60ml/min In Patients should not desire dosage modification of Lenangio

CrCl 30 to 60ml/min In Patients, 5mg of Lenangio should carry out orally as once daily

CrCl <30ml/min In-Patient, 2.5mg of Lenangio should be likely orally as a once daily.

Dosage difference

Thrombocytopenia

 Drops to <50000/mcL, treatment should be delayed. Back to > or equal to 50000/mcL, pursue the Lenangio of 5mg per day.

Neutropenia

Drops to <500/mcL, treatment should be delayed. Back to > or equal to 500/mcL, treatment should be followed to 5mg per day.

Multiple myelomas

This disease, contributing to the use of dexamethasone with Lenangio. The proper dose of Lenangio is 25mg should be likely as once in a day on day 1 to 21.

The dose of dexamethasone;

Dexamethasone 40mg should be progress on day 1 to 4, 9 to 12 & 17 to 20 of each stage of 28-day cycles. Patients with greater than 75 years, dexamethasone 20mg should be recommended on day 1, 8, 15, & 22.

Mantle cell lymphoma

The familiar dosage of Lenangio for this disease is 25mg should be inclined orally as once daily.

For renal broken patients

CrCl 30 to 60ml/min in the patient, Lenangio 10mg should be inured as once daily. CrCl <30ml/min in patients, Lenangio 15mg should be used for q48hr.

Pediatrics

The immunity & ability of Lenalidomide has not been depicted in pediatric patients with an age of <18 years.

MECHANISM

Lenangio 5mg associate with the diligence of tumor and factor alpha compromise, that supports the T-cells and leads to a decline in plasma levels of cytokines vascular endothelial development factor and basic fibroblast growth factor.

Lenangio 5mg is additionally bound with the prevent off angiogenesis.

Lenalidomide is additionally an authorized G1 cell cycle to conquer and apoptosis of ruinous cells.

PHARMACOKINETICS

Absorption

Absorbed immediately with peak plasma absorption is between 0.625 and 1.5 hrs. joining with food will not develop the prolong of consumption but a dose decreases in Cmax.

Distribution

Vault of plasma protein is 30%

Metabolism

chiefly metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide.

Excretion

Chiefly exclude in renal route and the dose secretes via urine 90% and feces 4% and the half-life is 3hrs.

DRUG INTERACTION

Communication of Lenangio 5mg with digoxin attend to increased absorption of digoxin causes an increased risk of unfavorable effects associated with digoxin.

The assistance of Lenangio 5mg with Erythropoietic agents, cause to formed progress in the risk of thrombosis. Discuss with the patients preceding to starting this combo treatment.

The cooperation of Lenangio 5mg with warfarin will produce increased liability of hemorrhage disorders. check the INR value & prothrombin time.

CONTRAINDICATION

When the pregnancy period the drug is contraindicated the patients are contraindicated to the hypersensitivity feeling and the Lenangio 5mg ingredient.

OVERDOSAGE

Overdosage of Lenangio 5mg will cause neutropenia & thrombocytopenia as chiefly common side effects. Give the patient a common supportive analysis. check the blood cells counts frequently during the analysis.

MISSED DOSE

The missed dose of Lenangio 5mg should be avoided. If missed dose founded, then patients should be consultative with doctor particular in oncologist organize the usual dosing schedule.

SIDE EFFECTS

Common side effects

Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infarction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Fatigue, Asthenia, Pyrexia, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout.

WARNING

Some of the common life-threatening condition like:

•             Venous & arterial thromboembolism

•             Blood clotting belongings

•             Embryo-fetal broken

•             Hypersensitivity reactions

•             Hematological disorders

•             For all these conditions, some supportive measures should be used and provide safety measures.

 PREGNANCY & LACTATION

Pregnancy:

Pregnancy type X Lenangio 5mg will produce serious fetal broken leads to death

Lactation:

While on Lenangio treatment analysis, Breastfeeding should not be suggested.

STORAGE

The drug stored at 20℃ to 25℃. Store the canister from light Protect away from humidity & heat.

 

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