Lenangio 25mg

  • Brand: Dr. Reddy’s
  • Brand Name Lenangio
  • Strength 25mg
  • Active substance Lenalidomide

265.00 USD
- +
Share

LENANGIO 25MG

DESCRIPTION

Lenangio 25mg belongs to an anticancer drug that includes Lenalidomide as active stuff that exists to the thalidomide analog.

Lenangio 25mg is used to the disease adapt by combining with dexamethasone.

Lenangio 25mg exists of some other pharmacological action like immunomodulatory & anti-angiogenesis.

Lenangio 25mg is a remedy drug that can only use under the administration of a medical oncologist.

INDICATION

The indications of Lenangio 25mg are

 Lenangio has been combined with dexamethasone is determined to treat the patients go through from multiple myeloma

 Lenangio is determined for the patients having transfer-reliant anemia because of intermediary 1 risk myelodysplastic syndrome along with with deletion 5q cytogenetic abnormality without or without addition cytogenetic abnormalities

 Lenangio is used to delight the patients with mantle cell lymphoma in which it is used who’s the disease was deterioration or proceed after two before analysis, principally the disease not sass with the bortezomib therapy.

MECHANISM

Lenangio 25mg includes in the prudence of tumor and factor alpha arrangement, that supports the T-cells and leads to abating plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast development factor.

Lenangio 25mg is additionally bound with the stave off angiogenesis.

Lenalidomide has additionally certified G1 cell cycle capture and apoptosis of ruinous cells.

Absorption: consumed rapidly with peak plasma concentration is between 0.625 and 1.5 hrs. combining with food will not change the prolong of saturation but does decrease in Cmax.

Distribution: prance of plasma protein is 30%

Metabolism: principally metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide.

Elimination: principally eradicate in renal route and the dose secrete via urine 90% and feces 4% and the half-life is 3hrs

DOSAGE & ADMINISTRATION

The adult usual dose of Lenangio 25mg in myelodysplastic syndromes is 10mg and execute once a day.

For renal injury patients:

CrCl >60ml/min In Patients should not need dosage modification of Lenangio

CrCl 30 to 60ml/min In Patients, 5mg of Lenangio should oversee orally as once daily

CrCl <30ml/min In-Patient, 2.5mg of Lenangio should be likely orally as a once daily.

Dosage difference:

Thrombocytopenia:

Drops to <50000/mcL, treatment should be broken.

Back to > or equal to 50000/mcL, displace the Lenangio of 5mg per day.

Neutropenia;

Drops to <500/mcL, treatment should be held up.

Back to > or equal to 500/mcL, treatment should be succeeding to 5mg per day.

Multiple myelomas:

In this disease, attendant use of dexamethasone with Lenangio.

The regular dose of Lenangio is 25mg should be likely as once in a day on day 1 to 21.

The dose of dexamethasone:

 Dexamethasone 40mg should be extended on day 1 to 4, 9 to 12 & 17 to 20 of each stage of 28-day cycles.

Patients with greater than 75 years, dexamethasone 20mg should be recommended on day 1, 8, 15, & 22.

Mantle cell lymphoma:

The usual dose of Lenangio for this disease is 25mg should be given orally as once daily.

For renal injury patients:

CrCl 30 to 60ml/min in the patient, Lenangio 25mg should be given as once daily.

CrCl <30ml/min in patients, Lenangio 15mg should be used for q48hr.

Pediatrics;

The immunity & adeptness of Lenalidomide has not been depicted in pediatric patients with age of <18 years.

SIDE EFFECTS

•             Second primary malignancies

•             Hepatotoxicity

•             Hypersensitivity feeling

•             Thyroid dysfunction

•             Fetal toxicity

•             Hematological toxicity

•             Tumor lysis syndrome

•             Tumor flare feeling

•             growth of mortality rate

Common side effects

•             Diabetes mellitus

•             Rash

•             Insomnia

•             Despair

•             Deep vein thrombosis

•             Myocardial infarction

•             Renal failure

•             Squamous cell carcinoma

•             Basal cell carcinoma

•             Fatigue

•             Asthenia

•             Pyrexia

•             Pain

•             Diarrhea

•             Dyspepsia

•             Bone pain

•             Neck pain

•             Respiratory infections

•             UTI

•             Influenza

•             Sepsis

•             Headache

•             Anemia

•             Loss of appetite

•             Hypokalemia

•             Hyperglycemia

•             Hypocalcemia

•             Dehydration

•             Gout

CONTRAINDICATION

When pregnancy stage the drug is contraindicated

The patients are contraindicated to a hypersensitivity reaction and the Lenangio 25mg component.

WARNING

Some of the common life-threatening condition like

Venous & arterial thromboembolism

Blood clotting effects

Embryo-fetal damage

Hypersensitivity reactions

Hematological disorders

For all these conditions, some supportive measures should be used and provide safety measures.

DRUG INTERACTIONS

Interaction of Lenangio 25mg with digoxin leads to increased concentration of digoxin causes an increased risk of adverse effects related to digoxin.

Interaction of Lenangio 25mg with Erythropoietic agents, cause to produced rises in the risk of thrombosis. Discuss with the patients before starting this combination treatment.

Interaction of Lenangio 25mg with warfarin will produce increased exposure to hemorrhage disorders. check the INR value & prothrombin time.

LENANGIO 25MG USES IN

Pregnancy

Pregnancy category X

Lenangio 25mg will produce serious fetal damage leads to death

Lactation

While on Lenangio treatment, Breastfeeding should not be recommended

STORAGE

The drug stored at 20oC to 25oC

Store the container from light

Protect away from moisture & heat.

MISSED DOSE

The missed dose of Lenangio 25mg should be avoided.

If missed dose founded, then patients should be consulting with a doctor specialized in an oncologist

Regulate the usual dosing schedule.

OVERDOSAGE

Overdosage of Lenangio 25mg will cause neutropenia & thrombocytopenia as mainly common side effects.

Give the patient general supportive treatment.

check the blood cells counts regularly during the treatment.

  • Lenangio
  • 25mg
  • Lenalidomide
  • 10 capsules in a strip
    No comments yet
Write a comment
Your name
Your name
Captcha

Sale of day

Choice of buyers. Only popular options!Choice of buyers.
Only popular options!

view all
Abbott
Astella
bayer
BDR
Biocon
Cipla
Dr. Reddy’s
Eisai
Eisai Pharma
Emcure
everest
Glenmark
GSK
Hetero
incepta
Intas
MSD
Mylan
Natco
Novartis
Strides
Sun Pharma
Zydus
  • Children born with HIV
    Children born with HIV
    Children born with HIV accessing treatment, have no significant difference in their movement skills, social interaction, language skills or practical reasoning at age five compared to HIV-negative children, according to new research....