Lenangio 25mg belongs to an anticancer drug that includes Lenalidomide as active stuff that exists to the thalidomide analog.
Lenangio 25mg is used to the disease adapt by combining with dexamethasone.
Lenangio 25mg exists of some other pharmacological action like immunomodulatory & anti-angiogenesis.
Lenangio 25mg is a remedy drug that can only use under the administration of a medical oncologist.
The indications of Lenangio 25mg are
Lenangio has been combined with dexamethasone is determined to treat the patients go through from multiple myeloma
Lenangio is determined for the patients having transfer-reliant anemia because of intermediary 1 risk myelodysplastic syndrome along with with deletion 5q cytogenetic abnormality without or without addition cytogenetic abnormalities
Lenangio is used to delight the patients with mantle cell lymphoma in which it is used who’s the disease was deterioration or proceed after two before analysis, principally the disease not sass with the bortezomib therapy.
Lenangio 25mg includes in the prudence of tumor and factor alpha arrangement, that supports the T-cells and leads to abating plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast development factor.
Lenangio 25mg is additionally bound with the stave off angiogenesis.
Lenalidomide has additionally certified G1 cell cycle capture and apoptosis of ruinous cells.
Absorption: consumed rapidly with peak plasma concentration is between 0.625 and 1.5 hrs. combining with food will not change the prolong of saturation but does decrease in Cmax.
Distribution: prance of plasma protein is 30%
Metabolism: principally metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide.
Elimination: principally eradicate in renal route and the dose secrete via urine 90% and feces 4% and the half-life is 3hrs
DOSAGE & ADMINISTRATION
The adult usual dose of Lenangio 25mg in myelodysplastic syndromes is 10mg and execute once a day.
For renal injury patients:
CrCl >60ml/min In Patients should not need dosage modification of Lenangio
CrCl 30 to 60ml/min In Patients, 5mg of Lenangio should oversee orally as once daily
CrCl <30ml/min In-Patient, 2.5mg of Lenangio should be likely orally as a once daily.
Drops to <50000/mcL, treatment should be broken.
Back to > or equal to 50000/mcL, displace the Lenangio of 5mg per day.
Drops to <500/mcL, treatment should be held up.
Back to > or equal to 500/mcL, treatment should be succeeding to 5mg per day.
In this disease, attendant use of dexamethasone with Lenangio.
The regular dose of Lenangio is 25mg should be likely as once in a day on day 1 to 21.
The dose of dexamethasone:
Dexamethasone 40mg should be extended on day 1 to 4, 9 to 12 & 17 to 20 of each stage of 28-day cycles.
Patients with greater than 75 years, dexamethasone 20mg should be recommended on day 1, 8, 15, & 22.
Mantle cell lymphoma:
The usual dose of Lenangio for this disease is 25mg should be given orally as once daily.
For renal injury patients:
CrCl 30 to 60ml/min in the patient, Lenangio 25mg should be given as once daily.
CrCl <30ml/min in patients, Lenangio 15mg should be used for q48hr.
The immunity & adeptness of Lenalidomide has not been depicted in pediatric patients with age of <18 years.
• Second primary malignancies
• Hypersensitivity feeling
• Thyroid dysfunction
• Fetal toxicity
• Hematological toxicity
• Tumor lysis syndrome
• Tumor flare feeling
• growth of mortality rate
Common side effects
• Diabetes mellitus
• Deep vein thrombosis
• Myocardial infarction
• Renal failure
• Squamous cell carcinoma
• Basal cell carcinoma
• Bone pain
• Neck pain
• Respiratory infections
• Loss of appetite
When pregnancy stage the drug is contraindicated
The patients are contraindicated to a hypersensitivity reaction and the Lenangio 25mg component.
Some of the common life-threatening condition like
Venous & arterial thromboembolism
Blood clotting effects
For all these conditions, some supportive measures should be used and provide safety measures.
Interaction of Lenangio 25mg with digoxin leads to increased concentration of digoxin causes an increased risk of adverse effects related to digoxin.
Interaction of Lenangio 25mg with Erythropoietic agents, cause to produced rises in the risk of thrombosis. Discuss with the patients before starting this combination treatment.
Interaction of Lenangio 25mg with warfarin will produce increased exposure to hemorrhage disorders. check the INR value & prothrombin time.
LENANGIO 25MG USES IN
Pregnancy category X
Lenangio 25mg will produce serious fetal damage leads to death
While on Lenangio treatment, Breastfeeding should not be recommended
The drug stored at 20oC to 25oC
Store the container from light
Protect away from moisture & heat.
The missed dose of Lenangio 25mg should be avoided.
If missed dose founded, then patients should be consulting with a doctor specialized in an oncologist
Regulate the usual dosing schedule.
Overdosage of Lenangio 25mg will cause neutropenia & thrombocytopenia as mainly common side effects.
Give the patient general supportive treatment.
check the blood cells counts regularly during the treatment.
- 10 capsules in a strip