Fludabine

Fludarabine injection/ tablet  is a anti viral agaent. It ct by inhibiting DNA Synthesis by interfering with ribonucleotide reductase and DNA Polymerase. read more

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Fludarabine 

Drug profile 

Fludarabine injection/ tablet  is a anti viral agaent. It ct by inhibiting DNA Synthesis by interfering with ribonucleotide reductase and DNA Polymerase.

 Indication

Fludarabine injection/tablet is indicated for the treatment of adult patient with b-cell chronic lymphocytic leukemia.

The safety and effectiveness of Fludarabine FOR INJECTION in previously untreated or non-refractory patients with CLL have not been established.

Dosage and administration

The recommended adult dose of Fludarabine INJECTION is 25 mg. administered intravenously over a period of approximately 30 minutes daily for five consecutive days. Dose Of FLUDARABINE May Be Increase Or Decreased Or Delayed Based On Patient Condition. 

Mechanism

Fludarabine injection/ tablet  inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine injection/ tablet  is active against both dividing and resting cells.This provides some level of specificity for blood cells, both cancerous and healthy. 

Side effect of Fludarabine injection/ tablet  

•             Nausea

•             Fatigue

•             Abdominal pain

•             Vomitting

•             Anemieadeacresed platlet count

•             Increased serum creatinin

•             Diarrhea

•             Upper respiratory tract infection

 

Common side effects

•             Heartburn

•             Headach

•             Skin rash

•             Back pain

•             Taste changes

•             Cough

•             Swelling

•             Dizziness

•             Constiption

•             Urinary tract infection

•             Shortness of breath

 

Precautions

•             Lung diseases occurred in 3-4% peoples .

•             Fludarabine injection/ tablet  should discontinue with patient having lung disease.

•             Cardiomyopathy: occurred in 1.4% of patientswith osimertinib . Left ventricular ejection fraction (lvef) should be assessed before treatment and then every 3 months thereafter.

•             Fludarabine injection/ tablet  can cause fetal harm when dministration to pregnant women.

•             Avoid breast feeding whi;e taking Fludarabine injection/ tablet  .

Storage

Store in cool place and air-tight container.

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