Abiraterone is sold under brand name Abirapro 500mg
Abirapro 500mg is exist to type of anti-cancer drug that will execution by slump the androgen production in the body. Androgen is a male hormone that can provide the tumor cell in prostate glands. This drug is given by co organization with prednisolone, a steroid which decrease the burden of side effects produced by Abiraterone.
Androgens are harmony the production of diseased in prostate.
Abirapro 500mg exist to anti androgen drugs, that purpose to contain the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is including in androgen conglomerate.
Decrease the serum testosterone level.
Refuse the tumor cell occurred.
Absorption: Time to maximum plasma combination of Abirapro 500mg tablet takes 12 hours.
Distribution: Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.
Metabolism: The main two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.
Excretion: The drug mainly excreted in 88% feces and 5% in urine
Half-life of tablet Abirapro 500mg is 12 ± 5 hours.
Side Effects occurred in Abirapro 500mg tablets
Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency, Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency
Muscular skeletal and Connective tissue disorders: Joint swelling, discomfort, muscle discomfort
General Disorder: Edema
Cardiac disorders: Hot flush, hypertension, arrhythmias, chest pain, cardiac failure
GIT disorders: Diarrhea, dyspepsia
Infections and Infestation: UTI
Pulmonary disorder: Cough
Renal: Urinary frequency, nocturia
DOSAGE AND ADMINISTRATION
The prescribed dose of Abirapro is initial as 4 tablets given orally once daily.
The drug Abirapro execute sequence with 5mg prednisolone twice daily in vacant stomach.
- Abirapro Tablets given on avacant stomach.
- Food should not be taken for at least 2 hours before and at least 1 hour after the dose of AbiraproTablets is taken.
- Consume whole with water.
- Chomp the tablets or Do not crush
Cooperation Abirapro 500mg with strong CYP3A inhibitors or inducers, concomitant use with prudence because pharmacokinetics is not estimated.
cooperation of Abirapro 500mg with dextromethorphan will accession the Cmax and AUC of dextromethorphan
SAFETY AND WARNING OF ABIRAPRO 500MG
Any allergy, severe liver problem or pregnant in patient, Abirapro 500mg therapy should be interrupted
Evadetaking of other drug, i.e. remedy, over-the-opposing, vitamins, herbal remedies, etc. be sure to inform the doctors before the analysis.
Do not take Aspirin execute and products include aspirin till doctor particularly allow the drug.
Abirapro 500mg has no vital antidote, if overdose develop end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.
If patient missed the dose of Abirapro 500mg, that missed dose will be skipped and follow the regular dosing schedule.
Pregnancy category X: while on therapy with Abirapro 500mg tablet if women become pregnant, immediately stop the drug and give counseling to the women. Abirapro 500mg tablet is not recommended for women.
Abirapro 500mg not used in women excretion in human milk is unknown and the drug effects in the nursing infant is unknown.
HANDLING OF STORAGE
The drug stored at 15oC-30oC
Keep the drug in dry place.
- Abiraterone acetate
- 60 tablets