abirapro-500mg

Abirapro 500mg  is exist to type of anti-cancer drug that will execution by slump the androgen production in the body. read more
  • Brand: Glenmark
  • Brand Name abirapro
  • Strength 500mg
  • Generic Abiraterone acetate

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ABIRAPRO 500MG

Description

Abiraterone is sold under brand name Abirapro 500mg

Abirapro 500mg is exist to type of anti-cancer drug that will execution by slump the androgen production in the body. Androgen is a male hormone that can provide the tumor cell in prostate glands. This drug is given by co organization with prednisolone, a steroid which decrease the burden of side effects produced by Abiraterone.

Mechanism

Androgens are harmony the production of diseased in prostate.

Abirapro 500mg exist to anti androgen drugs, that purpose to contain the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is including in androgen conglomerate.

Decrease the serum testosterone level.

Refuse the tumor cell occurred.

Pharmacokinetics

Absorption: Time to maximum plasma combination of Abirapro 500mg tablet takes 12 hours.

Distribution: Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.

Metabolism: The main two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.

Excretion: The drug mainly excreted in 88% feces and 5% in urine

Half-life of tablet Abirapro 500mg is 12 ± 5 hours.

Side Effects occurred in Abirapro 500mg tablets

Common effects

Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency, Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency

Muscular skeletal and Connective tissue disorders: Joint swelling, discomfort, muscle discomfort

General Disorder: Edema

Cardiac disorders: Hot flush, hypertension, arrhythmias, chest pain, cardiac failure

GIT disorders: Diarrhea, dyspepsia

Infections and Infestation: UTI

Pulmonary disorder: Cough

Renal: Urinary frequency, nocturia

Injuries: Fractures

DOSAGE AND ADMINISTRATION

The prescribed dose of Abirapro is initial as 4 tablets given orally once daily.

The drug Abirapro execute sequence with 5mg prednisolone twice daily in vacant stomach.

  • Abirapro Tablets given on avacant stomach.
  • Food should not be taken for at least 2 hours before and at least 1 hour after the dose of AbiraproTablets is taken.
  • Consume whole with water.
  • Chomp the tablets or Do not crush

DRUG INTERACTION

Cooperation Abirapro 500mg with strong CYP3A inhibitors or inducers, concomitant use with prudence because pharmacokinetics is not estimated.

cooperation of Abirapro 500mg with dextromethorphan will accession the Cmax and AUC of dextromethorphan

SAFETY AND WARNING OF ABIRAPRO 500MG

Any allergy, severe liver problem or pregnant in patient, Abirapro 500mg therapy should be interrupted

Evadetaking of other drug, i.e. remedy, over-the-opposing, vitamins, herbal remedies, etc. be sure to inform the doctors before the analysis.

Do not take Aspirin execute and products include aspirin till doctor particularly allow the drug.

OVERDOSAGE

 Abirapro 500mg has no vital antidote, if overdose develop end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.

MISSED DOSE

If patient missed the dose of Abirapro 500mg, that missed dose will be skipped and follow the regular dosing schedule.

PREGNANCY

Pregnancy category X: while on therapy with Abirapro 500mg tablet if women become pregnant, immediately stop the drug and give counseling to the women. Abirapro 500mg tablet is not recommended for women.

LACTATION

Abirapro 500mg not used in women excretion in human milk is unknown and the drug effects in the nursing infant is unknown.

HANDLING OF STORAGE

The drug stored at 15oC-30oC

Keep the drug in dry place. 

  • abirapro
  • 500mg
  • Abiraterone acetate
  • 60 tablets
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